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In this study, we tested exosome mediated drug delivery across the BBB in zebrafish Danio rerio.
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The blood—brain barrier BBB essentially restricts therapeutic drugs from entering into the brain. Conclusions Brain endothelial cell derived exosomes could be potentially used as a carrier for brain delivery of anticancer drug for the treatment of brain cancer. Greater intracellular fluorescence with rhodamine delivered by the highest concentration of exosome was confirmed by confocal microscopy Fig. The name says it all: Evaluation of human nasal RPMI cells grown at an air-liquid interface as a model for nasal drug transport studies. Will they have the mental strength to make it 21 days?