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Probably the most relaxed position to be in. AIN can be treated using topical therapies such as imiquimod, 5-flurouracil, and trichloroacetic acid, as well as ablative therapies such as electrocautery and laser therapy. A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women. Anal cancer is preceded by intraepithelial neoplasia[ 45 ], a premalignant lesion which has been described by a variety of different classification schemes throughout the literature owing to the evolving understanding of its underlying pathophysiology. Finally, human papillomavirus vaccination appears to reduce the rate of AIN and possibly anal cancer. It is important for clinicians to be familiar with AIN and the role of HPV vaccination, particularly in high risk populations. Topical therapy consists of direct application of a medication to either a specific lesion or to the entire anal canal.

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Topical therapy consists of direct application of a medication to either a specific lesion or to the entire anal canal.

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All authors declare no conflicts of interest for this article. Due to the low incidence of anal cancer, the changing nomenclature, the difficulties with validated testing, and the absence of large, population-based screening programs, it is difficult to estimate the true burden of AIN in the general population. Similar progression rates were described by Burgos et al[ 36 ] with progression occurring at With anal, I can go balls-deep without having to worry about hurting her. Interobserver variation in the reporting of the histopathological grading of anal intraepithelial neoplasia.

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